Wolfsburg will attempt to defend their small advantage, as they scored early on their turf and held off Lyonnes for the remainder of the game.
Match Replays
Barcelona have more than one foot in the semifinals, as they blew out Real Madrid on the road, piling on six goals and conceding twice last week.
Chelsea will try to stage a comeback in front of their fans after Arsenal prevailed 3-1 in the first leg of the London derby in the Round of Eight.
Bayern outlasted Man. United at home, emerging victorious with a 3-2 result, but the qualification remains wide-open heading into the return match.
Man. United prevailed handily in both matches versus Atlético Madrid in the past round. Bayern have had just one blemish in the competition so far.
Real Madrid and Barcelona renew their historic rivalry. The latter have been dominant so far, while the hosts edged out Paris FC in the playoffs.
Arsenal scored seven goals in the two legs versus OH Leuven. Chelsea are entering the knockout stage after closing the previous one in third place.
Wolfsburg eliminated Juventus in the playoffs thanks to a strong showing at home. Lyonnes are undefeated and finished second in the league phase.
Man. United have more than one foot in the quarter-finals after a great display in Madrid, as they struck early and didn't let up, winning three-nil.
Juventus jumped to an early two-nothing lead on the road, but Wolfsburg hit the net twice late, so the two teams are even heading into the return leg.
Arsenal just need to finish the job to reach the next stage of the competition after getting the best of OH Leuven with a four-nil result in Belgium.
Real Madrid conceded early last week, but then scored three goals in a row, building their advantage. Paris FC stayed alive by trimming the gap late.